Endocrine Abstracts

Endocrinopathies are becoming increasingly recognised with the use of new anticancer drugs. Ipilimumab therapy has recently been associated with hypophysitis. The presentation of hypopituitarism can be non-specific and diagnosis in an oncology setting may be challenging. We describe a 77-year-old man who presented to oncology with a short history of lethargy, nausea, anorexia, and weight loss. He had completed four cycles of ipilimumab as treatment for melanoma 7–9 months...

Background: In steroid dependent patients the knowledge of steroid dose change during illness and stress is of paramount importance.Objectives: i) To assess patient’s knowledge of steroid management during acute illness and stressful condition. ii) To evaluate whether there is a relation between patient knowledge and admission with documented adrenal crisis. iii) To improve medical access to information about patients on steroid at Emergency Departm...

Introduction: Prolactin is a multifunctional pituitary hormone. The effect of prolactin on platelet activation is not well understood. Prolactinomas are the most common type of pituitary adenomas, and they are medically responsive to dopamine agonists. Mean platelet volume (MPV) is a marker of platelet function and activation. The aim of this study was to evaluate MPV values before and 6 months of cabergoline treatment when normoprolactinemia was achieved.<p class="abstext...

Introduction: Brain metastases of thyroid carcinomas are rare (0.1–5%) according to the literature data. They generally occur in a context of metastatic spread which has a serious impact on survival. We report two cases and will review the literature data.Observations: Case 1: 57-year-old patient monitoring for papillary thyroid carcinoma in its solid form trabecular classified T4N0M1with lung metastases. Following a neurological symptoms of tonic-c...

Introduction: Papillary thyroid carcinoma (PTC) has generally good prognosis, and distant spread is rare. Common sites of distant metastasis are lung parenchyma and bone. Pleural metastasis is less common (0.6%), and most cases have been detected because of pleural effusion. Malignant pleural effusion is a poor prognostic factor among patients with PTC. We report a case of pleural metastasis of PTC proved by pleural biopsy.Case report: A 62-year-old man ...

Background: Integration between fat tissue, gastrointestinal tract, and the brain has attracted scientific interest in recent years. Thyroid hormones influence carbohydrate mechanisms via its interaction with adipocytokines and gut hormones. Adiponectin, ghrelin and obestatin play important roles in metabolism regulation. TSH receptors have been reported to be present in adipose tissue. Moreover, gut peptides signal to their functional cogna...

Background: Procalcitonin (PCT) is often an increased acute phase reactant in the bacterial infection-related inflammation, and its serum level is reported elevated in several autoimmune disease. However, the level of PCT and its relationship with autoimmunity remain unknown in Hashimoto’s thyroiditis (HT). Our objective was to investigate the serum levels of PCT and its association with autoantibodies in patients with euthyroid HT.Methods: A total ...

75 male was referred to endocrine service with incidental pituitary macroadenoma measuring 4.2×3.1×3.3 cm noted on MRI-C-Spine done for ankylosing spondylitis with Atlanto-axial joint instability. He had reduced secondary sexual characteristics and left quadrantanopia. Endocrine studies confirmed thyrotroph and gonadotroph failure but normal lactotroph and HPA axis. He underwent trans-sphenoidal tumour resection followed by external beam radiation due to tumour resid...

Background: Care of patients with diabetes should include an assessment of bone health. It is now clear that patients with type I DM have lower bone mineral density which may be manifested as osteopenia in growing skeleton and higher risk of fractures.Objective: To assess bone modelling through the measurement of bone formation and resorption indexes in diabetic children and their correlations with metabolic parameters.Methods: We ...

Introduction: Vitamin D insufficiency is common in older people and is associated with several disorders related to aging such as osteoporosis, which leads to a significantly increased risk of bone fractures. This deficiency is more common in Mediterranean countries than in Northern European countries. Hypocalcemic seizures resulting from vitamin D deficiency are rare in adults, and fractures caused by seizures without evidence of direct trauma have not yet been reported.<...